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reported acylcarnitine metabolite levels were reduced with mechanical circulatory support [6]
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This demonstrates the need to consider the use of a prodrug prior to clinical evaluation, especially in the case of the traditionally problematic phosphonic acid, in order to overcome the double negative charge at physiological pH
Notably, only the decrease in H3K4me3 was consistent across all tumour models
10.1016/j.nut.2018.03.058 52 TryfidouD
