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First-line pharmacologic options (evidence-based): Gabapentin/pregabalin , tricyclic antidepressants (e.g., amitriptyline/nortriptyline), and topical 5% lidocaine patches

[DOI] [PubMed] [Google Scholar] 4

Jacob R, Barrett E, Plewe G, Fagin KD, Sherwin RS

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At the molecular level, reduced NNMT activity shifts cellular methylation patterns, potentially altering epigenetic modifications via changes in SAM/S-adenosylhomocysteine (SAH) ratios

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