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Some treatments discussed, such as peptides, are considered investigational and are not FDA-approved

AOD9604 has been characterised across pre-clinical, safety pharmacology, and early-phase clinical research since the late 1990s, with peer-reviewed publications spanning lipid metabolism, adipose biology, joint repair, and bioavailability

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The surgical procedure was performed in rats that had food and water ad libitum before the procedure and until the end of the experiment, and assessments were performed by an observer unaware of the treatments used