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127 In addition, the HDL bioactive lipid, sphingosine-1-phosphate (S1P), which is complexed to apoM on HDL, also mediates activation of eNOS by interaction with S1P 1/3 receptors to induce PI-3K, Akt signaling

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25,26 The behavior and therapeutic potential of MSCs are tightly regulated by intrinsic and extrinsic factors, including microenvironmental cues, epigenetic modifications, and cytokine signaling, where MSCs release a diverse range of bioactive molecules, including growth factors, cytokines, and extracellular vesicles (EVs)