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Hu C, Hoene M, Plomgaard P, Hansen JS, Zhao X, Li J, et al

The amount of weight lost was the same for the participants taking GLP-1s or other weight loss drugs

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Like POLG mutations, other genetic abnormalities that impair mtDNA replication, including C10orf2 , DGUOK , MPV17 , PEO1 , and SUCLG1 , are part of the hepatocerebral mitochondrial DNA depletion syndromes, which are syndromes that include prominent liver failure (70, 75, 76)