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10.1186/s41065-025-00587-1 55 LiaoT.MaZ.LiuD.ShiL.MaoJ.WangP.et al (2024)

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Quinine Historically employed in malaria treatment, quinine is well-documented for its ototoxic potential, often presenting as reversible hearing loss and tinnitus

Early and extended red cell antigen typing is recommended to reduce the risk of alloimmunization, especially in transfusion-dependent patients

For example, Cys (239), one of the six cysteinyl residues, is poorly accessible when Hsp 33 is active, and remains reduced despite H2O2 exposure, and does not therefore react with the sixth cysteinyl, Cys (141 ), which is highly reactive toward chemical modifications, demonstrating that other factors such as amino acid sequence, and other amino acid/peptidyl properties also are important in protein folding

Hearing loss has also been linked with reduced job performance, tension, stress, and reduced alertness