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The target cell expresses a Frizzled receptor as well as the co-receptor LRP5/6

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Initial crystallization conditions were optimized manually by mixing protein and reservoir solutions in 1:1 (v:v) ratios

Watch for early warning signs such as: Dark-colored urine Dry mouth Fatigue Muscle cramps Headache Feeling lightheaded or dizzy Reduced performance during work or exercise The best way to stay ahead of dehydration is to drink fluids consistently throughout the day, replace electrolytes during prolonged sweating, take breaks in the shade or air conditioning, and recognize when symptoms require medical attention