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Science 1998, 280 (5365), 915918

Nature 1993

Some clinical trials testing formulations that included N-acetylcysteine have found modest improvements in cognitive function, but clinical trials testing it alone have shown less robust results

Key risk factors for developing NAFLD include: Obesity , particularly central adiposity (excess abdominal fat) Type 2 diabetes mellitus and insulin resistance Dyslipidaemia (abnormal cholesterol and triglyceride levels) Metabolic syndrome (a cluster of conditions including hypertension, hyperglycaemia, and abnormal lipids) Sedentary lifestyle and poor dietary habits The underlying pathophysiology involves insulin resistance, which leads to increased delivery of free fatty acids to the liver, enhanced hepatic fat synthesis, and impaired fat oxidation