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In GF mice, the absence of commensal bacteria specifically leads to underdeveloped mucosal lymphoid structures, including Peyers patches and germinal centers, as well as reduced secretory immune factors [35, 39]

That does not invalidate the findings, but it is relevant context for how to interpret them [19]

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Deficiency in vitamin B12 may cause anemia, fatigue, muscle weakness, intestinal problems, nerve damage, and mood disturbances
