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Next, a specialized transport antiporter protein called Carnitine-Acylcarnitine Translocase (CACT) ferries this acylcarnitine complex across the impermeable inner membrane and deep into the mitochondrial matrix, while simultaneously pumping a free L-carnitine molecule back out to maintain the cycle

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

However, it is unable to completely prevent TMAO formation and does not inhibit the formation of TMA from -butyrobetaine [115,125]

Diets rich in TMA precursors, such as choline and L-carnitine, are the main sources of TMAO (Zhang et al., 1999

doi: 10.1016/0167-4889(85)90153-3
