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Thus, a metabolomics perspective was used in this study

Tumor Lactic Acidosis Suppresses CTL Function by Inhibition of P38 and JNK/c-Jun Activation

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In addition to IGF pathways, anti-tumor effects on PI3K/AKT/mTOR and MAPK/ERK pathways with metformin exposure were observed, leading to the upregulation of markers of cell cycle arrest, apoptosis, and autophagy and downregulation of markers associated with senescence and the inhibition of cell migration (Hanna et al., 2012