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Activation of ERK is dependent on the RAS/MAPK pathway, in which IIS results in phosphorylated IRS or SHC that recruit growth factor receptor-bound protein 2 (GRB-2)

Chem Rev 102(12):46394750 Vicik R, Busemann M, Baumann K, Schirmeister T (2006) Inhibitors of cysteine proteases

High ROS induce NF-B signaling activation, up-regulate inflammatory cytokines (TNF-, IL-1) which promote inflammation, and further induce the abnormal expression of VEGF, induce abnormal angiogenesis (74)

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537,538 Both preclinical and clinical research supports the use of Pycnogenol for cognitive support