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Plasma acylcarnitines contribute to insulin resistance in obesity and T2D

Indeed, the PDH complex, which decarboxylates glycolytically derived pyruvate to acetyl coenzyme A and links cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle, is modulated by reversible phosphorylation by PDH kinase (PDK)

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questions still loom about their transport and regulation in T2D

doi: 10.1016/j.bbamcr.2016.01.023