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Moreover, microbial transplantation studies in germ-free mice with human commensals containing a functional (but not a deletion mutant) microbial cutC gene (responsible for cholineTMA transformation) (23) and genetic manipulation (both gain of function and loss of function) of host hepatic flavin monooxygenase 3 have been shown to modulate host TMAO levels, platelet responsiveness, and thrombosis potential in vivo (24)

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In a healthy body, the heart and skeletal muscles rely heavily on the breakdown of fats for their energy needs

This study shows for the first time what a dramatic effect changing your diet has on levels of TMAO, which is increasingly linked to heart disease, said Stanley L

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