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In a similar manner, the increase in brain magnesium (whole brain and prefrontal cortex) resulting from magnesium malate administration may engender global calming effects

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2.) Thiol-disulfide exchange reaction with enzymes and structural proteins

A single acute high-intensity interval exercise increases AMPK, Acetyl CoA carboxylase (ACC), Ulk1 protein expression, and Drp1 phosphorylation, promotes mitochondrial fission and mitophagy, and improves the anti-fatigue ability of skeletal muscle of mdx52 mice ( 5.1.3 Resistance exercise intervention Resistance training positively modulates mitophagy

Target validation: Comparison of target predictions with observations from previous literature As an initial validation, several of the genes in Table 1 were identified as proven drug targets in the literature and some have previously identified inhibitors in Leishmania or other related species