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Experimental and molecular pathology, 93:193-199

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Pharmacokinetic studies revealed [6] : Orally administered AOD9604 was well absorbed in pigs with rapid degradation kinetics Primary degradation products were peptide fragments missing 2-3 amino acids from termini Both degradation products retained some reduced anti-lipogenic activity Rat whole-body radiography showed similar organ distribution patterns following both intravenous and oral administration This distribution pattern supports systemic absorption via the oral route in laboratory models

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.von Bartheld C.S., Bahney J., Herculano-Houzel S

Neutrophils isolated from the streptozotocin-induced diabetic rats model demonstrated an impaired metabolic profile