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J Neurochem 92(3):477486 Taniguchi H, Mohri I, Okabe-Arahori H, Aritake K, Wada K, Kanekiyo T, Narumiya S, Nakayama M et al (2007) Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury

Figure 1 provides a summary of the pathways and demonstrates which pathways are targeted by the better studied treatments

As a strong antioxidant, glutathione plays a critical role in protecting cells from oxidative stress, which is implicated in the aging process and may contribute to the pathogenesis of many diseases

Astrocytes play a critical role in protecting the brain against oxidative stress

Notably, prophylactic administration of curcumin prior to amyloid- deposition demonstrates preventive potential for Alzheimer's disease, possibly through facilitating amyloid-42 clearance from the brain to peripheral circulation (Mei et al., 2020)