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Key Points Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of pancreatic cells An accumulating body of evidence suggests that T1DM is associated with loss of tolerance by autoreactive B cells Although islet antigen-reactive B cells give rise to autoantibody secreting cells, their most important contribution to pathology in T1DM seems to be presentation of self-antigens to T cells Loss of tolerance of islet-reactive B cells is associated with certain genetic polymorphisms B cells contribute to diabetic kidney disease (DKD) through the production of antibodies that lead to the formation and deposition of immune complexes in the kidney In a clinical trial, B cell-depletion therapy showed some efficacy in patients with T1DM

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doi: 10.1016/j.freeradbiomed.2006.02.012 36 KosenkoEFelipoVMontoliuCGrisolaSKaminskyY

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Pre- and post-exposure administration of a mAb against MERS-CoV protected mice from challenge, as assessed by lung viral load, lung pathology and weight loss 107