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Metformin directly inhibits mitochondrial electron transport chain complex I and subsequently induces protective autophagy in the liver through the AMPKmTORC1 signaling axis, effects that extend lifespan in animal models and are associated with a reduced risk of metabolic syndrome, cardiovascular disease, and cancer in human populations (Madeo et al., 2019)

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The two categories act synergistically, thus forming the core system of natural products for intervening hepatic metabolic barrier injury

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10.1136/jmedgenet-2017-104863 145

By bridging the existing knowledge gap, this review provides a comprehensive understanding of how green nanotechnology can revolutionize horticultural crop management while maintaining ecological balance