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Neither version has demonstrated clear superiority in published data

Lovicu, M

They act by stimulating the release of growth hormone (GH) from the pituitary gland, increasing levels of insulin-like growth factor-1 (IGF-1), which promotes muscle protein synthesis, enhances recovery, and supports tissue regeneration
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While their mechanisms of action are similar, topical acetyl hexapeptide-8 does demonstrate a lower efficacy than injected Botox, but as researchers note this is to be expected.22 Similar results were found in a small 2013 study, with the total anti-wrinkle efficacy of the Argireline treatment group being 48.9% compared to 0% in the placebo group.23 However, a more recent 2023 study investigating the effects of serum containing Argireline and hyaluronic acid found the results to be not statistically significant.24 This means that more research is needed before claims that Argireline is a true alternative to Botox can be confirmed or denied

In September 2023, the FDA added 19 peptides to Category 2effectively banning compounding pharmacies from working with them