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Identification of a Mutation in the Extracellular Domain of the Epidermal Growth Factor Receptor Conferring Cetuximab Resistance in Colorectal Cancer

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Specifically, low membrane expression of B7-H5 is significantly negatively correlated with several indicators of disease severity, such as elevated hematocrit, BUN, creatinine, and lactate levels and increased Ranson and APACHE II scores, 156 highlighting the potential role of innate immunity-mediated downregulation of the membrane expression of B7-H5 in immune dysregulation during SAP