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Video abstract Similar content being viewed by others Introduction The onset and development of tumors are dependent on the impairment in the ecological balance of the bodys microenvironment, wherein metabolic reprogramming and the bodys immune response play important roles

Both belong to a new generation of injectable peptide-based therapies that work by targeting multiple hormonal pathways simultaneously, offering potentially greater metabolic benefits than earlier single-receptor agents

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Studies show that Galunisertib markedly attenuates bleomycin-induced pulmonary fibrosis in mice, an effect that relies predominantly on inhibition of TGF-/Smad signaling

VEGF also promotes the expression of PD-1 in tumor cells, which leads to T cell exhaustion and ultimately destroys the anti-tumor immune response, resulting in immune cell inhibition (186)

[DOI] [PubMed] [Google Scholar] 9.Paus R., Cotsarelis G