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Here we have identified that depletion of -ketoglutarate (KG) sensitizes HR-proficient cells to DNA-damaging agents by metabolic regulation of histone acetylation

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In the same animal model an improvement of mitochondrial respiration and muscle function has been also observed [51]

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Iwamoto H, Abe M, Yang Y, Cui D, Seki T, Nakamura M, et al

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