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doi: 10.3389/fnut.2026.1804917 Received 05 February 2026 Revised 04 March 2026 Accepted 16 March 2026 Published 31 March 2026 Volume 13 - 2026 Edited by Berenice M Romn Calleja, National Institute of Medical Sciences and Nutrition Salvador Zubirn, Mexico Reviewed by Anindita Banerjee, Indian Council of Medical Research (ICMR), India Venkateswararao Eeda, University of Oklahoma Health Sciences Center, United States Updates Copyright 2026 Chen, Zou, Li, Liu, Liu, Yao, Peng, Liang, Chen, Huang and Huang

How Creatine May Support Fat Loss Indirectly While creatine doesn't burn fat directly, it can create conditions that support fat loss over time

Secondly, although the downstream mevalonate pathway intermediate HMG-CoA is rapidly depleted in the absence of ACLY and acetate, acetyl-CoA levels decrease more moderately upon acute acetate withdrawal 8

Taking it as a dietary supplement is particularly important for vegetarians and vegans

Additionally, the evidence was too limited to assess the impact on quality of life or mental and physical fatigue

This means taking action to improve your glycemic control if your fasting glucose is over 86 mg/dL or your HbA1C is higher than 5.4%
