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Similarly to the pentose phosphate pathway, which leads to the synthesis of NADPH and precursors for the synthesis of nucleotides, and DHAP, which leads to the synthesis of triacylglycerols, the formation of MGO is also expected as a necessary metabolic diversion in the case of an excess of saccharides

With respect to energy generation, pyruvate, derived from carbohydrate oxidation, and fatty acids are imported into the mitochondria from the cytosol and converted to acetyl-CoA in the mitochondrial matrix through the actions of the PDHc and the enzymes of fatty acid oxidation

doi: 10.1056/NEJMra2026131 77 FakhrolmobasheriM.Mazaheri-TehraniS.KieliszekM.ZeinalianM.AbbasiM.KarimiF.et al

PMID: 113 HuangXZhangYJiangYLiTYangSWangYet al

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