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Description
Proposed mechanisms include circulatory disturbances in liver cirrhosis, metabolic and neurohormonal (renin-angiotensin-aldosterone system) dysfunctions, excessive nitric oxide production, oxidative stress, and inflammatory mediators [11, 171]

Horwitz, M.D., Stephanie P

doi: 10.1016/j.metabol.2017.11.018 37 FelederCJarryHLeonhardtSMoguilevskyJAWuttkeW

Brain glucose transporters: role in pathogenesis and potential targets for the treatment of alzheimers disease

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While the precise pathological mechanisms underlying various complications associated with PA remain incompletely understood, it is clear that the accumulation of propionyl-CoA and its toxic metabolites plays a significant role as pathogenic factors
