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Results KAT6A mutations cause a decrease in histone H3 lysine 23 (H3K23) acetylation in human cells and mice To determine the effects of mutation of the KAT6A gene on histone acetylation, we generated human HEK293T cells carrying six different KAT6A variants observed in individuals with ARTHS using CRISPR/Cas9 and homology-directed repair (Tables S1, S2, and S3)

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[DOI] [PubMed] [Google Scholar] Tan X., Liu Y., Long J., Chen S., Liao G., Wu S.Zhu H

Gastric antral vascular ectasia causes dilated vessels with fibrin thrombi and fibromuscular hyperplasia of the lamina propria [202]

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Using isotope tracer studies, clinical studies, and animal models employing germ-free mice, we demonstrate a role for gut microbiota metabolism of L-carnitine in atherosclerosis pathogenesis