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Resveratrol, the most common SIRT1 activator, not only relieves the brain microvascular endothelial dysfunction and the permeability of the BBB to inflammatory cells caused by ABCD1 deletion through enhancing SIRT1 function to regulate NF-B signal pathway (99) but also normalizes axonal degeneration and locomotor deficits via activation of SIRT1/PGC-1 pathway to promote mitochondrial biogenesis and function in ABCD1-/ABCD2-/- mice (89)

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[DOI] [PubMed] [Google Scholar] 31.Arndt KA, Fitzpatrick TB

However, chronic GH treatment carries substantial risks, including glucose intolerance, insulin resistance, diabetes, cancer, and cardiovascular complications