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In this case, the nonenzymatic antioxidants take over the fight against ROS

Sources & References: DSM

To overcome cellular impermeability to folate, vertebrates rely on multiple high-affinity transport systems: the reduced folate carrier (RFC), the proton-coupled folate transporter (PCFT), and folate receptors (FRs) [3,4,5,6]

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Increased spinal cord Na (+) -K (+) -2Cl () cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain