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Feature attribution analysis revealed 19 variables in the T2D cohort and 10 variables in the IHD cohort that contributed more than 4% of regularized TMAO SD to model outcome (Fig

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The cyclic lactam constraint between the Asp and Lys side chains preorganizes the conserved His-Phe-Arg-Trp (HFRW) message tetrapeptide of -MSH into the receptor-bound conformation, which is responsible for the dramatic potency increase relative to the linear native hormone

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Simpson, D