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Circulating levels of IGF1 have been linked to the development of SPCs in men with head and neck squamous cell carcinoma 20

They found that the combination of these growth factors displayed a more significant maximum load and tensile stress and inhibited scar formation compared to the IGF-1 alone group, suggesting that combination of IGF-1 and TGF- is more effective than IGF-1 alone in the treatment of tendon injury (Xiang et al., 2018)

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In addition, SOD proteins have the ability to bind to cell surface proteoglycans and extracellular matrix components in a positively-charged C-terminal region (extracellular matrix binding region)

The intervention group showed significantly lower severe hematologic toxicities (5% vs 23%, p = 0.03) and improved treatment completion rates compared to the placebo group