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* very poor solubility in culture medium (drug precipitation) and toxicity against cells

Even when refrigeration is suggested, proper sealing and single-dose handling are still important

BioPerine is a clinically tested black pepper extract containing at least 95% piperine, which significantly enhances the bioavailability of curcumin and other nutrients

Its epigenetic modulation of glutamatergic function is linked to its antidepressant, analgesic, and neurogenic properties [158, 163, 165, 169, 179-183]

10.1016/j.jacc.2018.04.061 20 GencerB.DjousseL.Al-RamadyO
