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doi:10.1007/BF02857783

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Finally, UDP-glucuronate is generated from UDP-glucose by UDP-glucose dehydrogenase, a NRF2-regulated enzyme [70, 71]

97 Although 8-oxoG can be repaired by the 8-oxoguanine DNA glycosylase 1-mediated base excision repair pathway, it continues to accumulate during aging and disease progression
Concurrently, the accumulated PUFAs serve as abundant precursors for pro-inflammatory eicosanoids, such as leukotriene B4 (LTB4), which recruits and activates neutrophils, thereby directly reinforcing the immune arm of the pathogenic axis

The second part of the aforementioned simplest oxidation-mediated thioldisulfide conversion mechanism is an electrophilicnucleophilic condensation reaction between RSOH and another thiol to give the disulfide (Reaction 4, where RSOH is the electrophile and RSH is the nucleophile)
