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Protein quantification was carried out using the MaxLFQ algorithm as implemented in the DIA-NN R package ( and the number of peptides quantified in each protein group was counted as implemented in the DiannReportGenerator package ( 71

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Studies have shown treatment of germ cells with selenium can increase GPX4 expression, maintain spermatozoal motility, and increase germ cell proliferation, indicating the xCT/GPX4 system plays a role in male infertility [80, 81]

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Ilaria, Gloria G, Marianna C, Chiara G, Frida L, Danila C