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They are usually discussed for different reasons

If your protocol calls for a 2mg dose and your concentration is off by even 10% due to a calculation error, your results will be skewed

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Synthetic B12 is still effective but may require more processing by the body, making it less accessible for some people
Mitochondrial Dysfunction in Type 2 Diabetes and Obesity Well established data demonstrate that mitochondrial dysfunction, particularly as it relates to the processes of oxidative phosphorylation, is contributory to the development of encephalomyopathy, mitochondrial myopathy, and several age-related disorders that include neurodegenerative diseases, the metabolic syndrome, and diabetes

Medical Science Monitor: International Medical Journal of Experimental and Clinical Research , 16 (3), BR81-88.