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CHS can lead to high healthcare resource utilization, causing enormous economic losses for both the healthcare system and the patient

Chuang, K.-H

Maski, Kiran, et al

It is associated with a significant increase in serum inflammatory biomarkers such as C-reactive protein (CRP) and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor (TNF)

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