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Physical and psychological challenges can activate the HPA axis reflexively leading to production of corticotrophin releasing hormone (CRH), ACTH hormone, and thereby glucocorticoid secretion [103]

Issues of low sperm count, poor motility and high rates of abnormal morphology contribute to male factor infertility, which is implicated in up to 50% of cases where couples are struggling to conceive

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For some, eliminating pain entirely represents the goal