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impermeants that can be included in the physiologically acceptable solutions provided herein include, without limitation, lactobionate, raff nose, hydroxyethyl starch (HES), gluconate, saccharate, and sorbitol

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VCN has been mainly implicated in clinical and preclinical studies for the treatment of several Central Nervous System (CNS) disorders, such as cerebral ischemia, epilepsy, Alzheimers disease, and Parkinsons disease 28

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3234 It achieves the therapeutic effects through two main activities: 1) mucolytic action conferred by the free sulfhydryl group which reduces disulfide bonds in the cross-linked mucus glycoproteins matrix, thus decreasing the viscosity of mucus
