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Homeostasis is maintained by the tissue effects of thyroid hormones (with peripheral T4/T3 conversion) and urinary excretion

doi: 10.1097/MPH.0000000000000750

Roles of NNMT in Energy Metabolism and the Related Mechanisms As a precursor of NAD + , NA methylation plays important roles in regulating energy metabolism because methylated NA is no longer able to be salvaged into NAD + [16]
Wright HH, Still CN, Abramson RK (1981) Huntingtons disease in black kindreds in South Carolina

analyzed the intervention effects of Dioscorea extract on aging rats with chronic atrophic gastritis based on the Shh pathway and found that Dioscorea extract regulated the secretion of gastric juice, gastric acid, and pepsin, while inhibiting the progression of the disease (Li et al., 2017)

doi: 10.1016/j.bbalip.2012.08.016 52
