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For neoplastic effects, EFSA selected a BMDL 10 of 1.31 mg/kg bw per day for increased incidence of hepatocellular adenomas and carcinomas in female mice after 2 years as reference point

However, despite encouraging early laboratory findings, its clinical development was discontinued in 2007 after failing to demonstrate significant weight-loss efficacy in large-scale human trials

Multiple treatment modalities for hyperpigmentation that shift eumelanin to pheomelanin synthesis exist

Pharmacol 1975, 31, 352360

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