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Single-cell chromatin modification profiling reveals increased epigenetic variations with aging

PMID: 32720683 Chang M, Russo GS, Canseco JA, Nicholson K, Sharma R, Koomson J, Vaccaro A.R

[DOI] [PMC free article] [PubMed] [Google Scholar] [2].Perl A

Specific mechanisms may involve oxidative damage caused by excessive ROS production, and the persistent accumulation of such damage can lead to further cellular and organismal dysfunction, ultimately inducing various diseases [34]

Under pathological conditions, microgliaas a function of different stimuliare activated to exert neuroprotective effects (M2 phenotype) or to release inflammatory factors and neurotoxic substances (M1 phenotype)

Start with simple changes: eat antioxidant-rich foods like berries and leafy greens, add sulfur-rich vegetables such as broccoli and garlic, get 79 hours of sleep, manage stress, and avoid smoking, alcohol, and heavily processed foods