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Similarly, in breast cancers, it was also found that MET mutation or amplification promotes tumor metastasis into more diverse organs

Tumor mutational landscape is a record of the pre-malignant state

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An earlier study demonstrated that microRNA-27a (miRNA-27a) expression promoted tumor angiogenesis and metastasis in vivo by mediating endothelial trans-differentiation of breast cancer stem-like cells (Tang et al., 2014)

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