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Although the differential activation between arthritic and healthy joints was not assessed, this example demonstrates the potential utility of applying aPS designs to noncancer pathologies

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The 100 mg/kg bw/day used in the prevention study came about after an evaluation of the intervention study results and with the knowledge that Cremer, et al, [35], used up to 180 mg/kg bw/day for 24 months led to no observable effects of ALA on histology or pathology