glutathione s transferases and drug resistance as mediators of signaling pathways involved in cell proliferation cell death Expression of drug resistance gene
Description
Surprisingly, CTLA-4 blockade has been observed to increase the expression and activity of the enzyme indolamine 2,3-dioxygenase (IDO), which could further contribute to immune exhaustion (234)
Or, and this is a bigger question, might carnivores already sidestep many of the underlying metabolic issues that make higher-dose supplementation so impactful in the first place

Mitochondrion 11 , 327333 (2011)

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Deodhar S, Dash AK (2018) Long circulating liposomes: challenges and opportunities

Differential gene expression profiling in human brain tumors