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GSEA analysis revealed significant enrichment of IFN-I signaling pathways in the Lig group (Fig S6a), while the corresponding heatmap analysis confirmed upregulation of IFN-Iresponsive genes in Lig-derived neutrophils (Fig S6b)

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GSH is present mainly (~85%) in the cytoplasm at a millimolar concentration and then distributed into mitochondria (~1015%) and endoplasmic reticulum and nucleus (~5%) (Figure 2B) [17]

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