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suggested that standalone vitamin E supplementation in ICU patients with sepsis was associated with a reduction in 28-day mortality (He et al., 2025)

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It plays a crucial role in tissue repair , antioxidant defense , and cellular regeneration

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These circulating mtDNA fragments are also known as danger-associated molecular patterns (DAMP) and are similar to the pathogen associated molecular patterns (PAMP) which are released by microbes and identified by pathogen recognition receptors (PRR) on the immune cells

A promising approach to enhancing therapeutic outcomes involves targeting mechanisms of CICD, including inducing ferroptosis by SLC7A11 inhibition, modulating mitochondrial ROS generation, or combining inhibition of autophagy with chemotherapy