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The major advantage of this approach is that small molecules have a considerable higher bioavailability compared to antibodies, dominant-negative receptors and antisense oligonucleotides

[39] Diseases with disturbed epidermal barrier/keratinization disorders Ichthyoses The effect is due to the anti-proliferative effects of n-acetylcysteine which diminishes the hyperkeratosis of lamellar ichthyosis and improves the skin barrier function

A standard view of systems or network biology (for example, Kell (444) and Kell & Knowles (445) ) develops these ideas in four stages

The lack of a stable triple-helical structure jeopardizes the stability of the skin, mucous membranes, blood vessels, and bone