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When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced
In any case, search for specific bacterial and protozoa NADase inhibitors may also be of great importance
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Research protocols often begin with 0.25mg and may scale to 0.5mg or 1mg, depending on the experimental model and study goals
