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Furthermore, in FXN -silenced SH-SY5Y cell lines, Trolox, a lipid peroxidation scavenger and analogue of Vitamin E, improved Ca 2+ uptake and reduced lipid peroxidation (Rodrguez et al., 2020b)
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1991 (landmark Italian trial): A double-blind, placebo-controlled trial involving 130 patients with Alzheimer's disease demonstrated that one year of ALCAR treatment resulted in a slower rate of deterioration compared to placebo across 13 of 14 outcome measures, including significant improvements in the Blessed Dementia Scale, logical intelligence, verbal critical abilities, long-term verbal memory, and selective attention [5][17]
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Moreover, alterations in topoisomerase II, which is the primary target of epirubicin, can lead to resistance
