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Dual-pathway synergy: Veldhuis and colleagues demonstrated in human physiological studies that simultaneous activation of GHRH receptor and GHS receptor pathways produces GH pulse amplitudes exceeding additive predictions

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Male and female mice were placed one by one in separate cages and mated

Consistent with these findings, GSH-depleted mice showed significantly decreased weights of liver and epididymal (visceral) white adipose tissue (eWAT) (Figure 2, D and E), while weights of inguinal (subcutaneous) white adipose tissue (iWAT), brown adipose tissue (BAT), or skeletal muscle remained unchanged (Supplemental Figure 2, FH)
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